GSVA (Fig. 5G) revealed a potential positive correlation between ZNF451 expression and several key biological pathways, including ubiquitin-mediated protein degradation and various cancer-associated pathways such as acute and chronic myeloid leukemia, endocrine cancers, non-small cell lung cancer, pancreatic cancer, prostate cancer, colorectal cancer, and glioma. This evidence concerns the gene ZNF451 and malignant endocrine neoplasm.