Yang et al. (2022) showed that DOX-Lip links with macrophages through DSPE-PEG-STA interactions (Figure 2A) and deeply penetrates the tumor cells to release DOX, thereby activating robust immune responses through the CD4+/CD8+/NK cells. MA-DOX-Lip effectively inhibited the tumor growth model of 4T1 triple-negative breast cancer in mice and improved the killing rate of the tumor cells (Figure 2A). The gene discussed is CD8A; the disease is neoplasm.