YTHDC1 and rheumatoid arthritis: In exploring YTHDC1’s role in the apoptosis of RA-FLSs, we noted that YTHDC1 overexpression led to augmented apoptosis, evidenced by elevated levels of the pro-apoptotic proteins Bax, Caspase3, and Cleaved-caspase3, and a decline in the anti-apoptotic protein Bcl-2 (Figure 6C).