Moreover, up-regulation of SOX11 affects B-cell development by preserving PAX5 expression and inactivating Blimp1, thereby preventing B cells from undergoing terminal differentiation, whereas antitumor genes are down-regulated in SOX11-expressing mantle cell lymphoma with significant immune infiltration.69, 70, 71 Consequently, eccDNA-mediated SOX11 upregulation enhances the tumor immune microenvironment's immunosuppressive effects and reduces tumor immunotherapy efficacy. The gene discussed is SOX11; the disease is neoplasm.