AKT1 and neoplasm: Consequently, the overexpressed MET proteins aberrantly activate downstream signaling pathways, including PI3K/AKT, RAS/ERK/MAPK, Wnt/β-catenin, SRC, and STAT3.20, 21, 22, 23, 24, 25, 26, 27, 28 This can ultimately engender cellular over-proliferation, stimulate tumorigenesis, invasion, and migration, and bolster drug resistance in tumor cells.80