Moreover, in a mouse model of B-cell lymphoma, certain miRNAs suppressed by MYC displayed substantial anti-tumor activity.99, 100, 101 In conclusion, eccDNA-induced activation of MYC leading to the silencing of oncogenes can bolster resistance to apoptosis in cancer cells, fostering the emergence of drug resistance in these cells. Here, MYC is linked to B-cell non-Hodgkin lymphoma.