Elevated IL-6 levels lead to JAK/STAT3 pathway activation, which unfavorably affects diverse immune cells like neutrophils, natural killer cells, and dendritic cells, ultimately diminishing anti-tumor immune defenses.62, 63, 64, 65 Additionally, STAT3 plays a pivotal role in the augmentation of myeloid-derived suppressor cells and Tregs.66 This evidence concerns the gene STAT3 and neoplasm.