Therefore, independent poor-risk factors affecting the overall survival of MM patients with 1q+ were found to be GNB1L (P < 0.001; hazard ratio: 1.2; 95% confidential interval: 1.1–1.3), CDC5L (P = 0.009; hazard ratio: 1.1; 95% confidential interval: 1–1.2), and E2F1 (P = 0.018; hazard ratio: 1.1; 95% confidential interval: 1–1.1). The gene discussed is E2F1; the disease is Miyoshi myopathy.