An increasing number of studies have shown that m6A modification may be of great importance for the development of MM.5, 6, 7 Insulin-like growth factor 2 messenger RNA binding proteins (IGF2BPs) are a class of RNA-binding proteins that include IGF2BP1, IGF2BP2, and IGF2BP3, which regulate the localization, translation, or turnover of their target transcripts.8 The gene discussed is IGF2BP1; the disease is Miyoshi myopathy.