Functionally and mechanically, through a combination of high-throughput assays, including RNA-seq, Clip-seq, and MeRip-seq, we found that IGF2BP1 promoted the proliferation of MM cells in vitro and in vivo by acting as a post-transcriptional enhancer of the CDC5L protein in an m6A-dependent manner in MM cells with 1q+. The gene discussed is CDC5L; the disease is Miyoshi myopathy.