TJP1 and neoplasm: Escamilla et al. (2012) used LGG to reduce the infiltration, invasion, and metastasis capabilities of tumor cells by reducing the expression of MMP9, inhibiting the degradation of IκB, and increasing the expression levels of IL-8 and ZO-1 (Escamilla et al., 2012). Consistent with the above results, in this experiment, LGG addition significantly decreased the relative expression of MMP9 in the liver; under LPS stimulation, LGG addition significantly decreased the relative expression of MMP9 in the liver, indicating that LGG may have a liver protective effect.