Recent CSF AD biomarkers time course study involving Chinese participants during the 20 years preceding clinical diagnosis of sporadic Alzheimer’s disease, showed changes in CSF biomarkers concentration, as follows: Aβ42, 18 years; Aβ42/Aβ40 ratio, 14 years; p-tau 181, 11 years; t-tau, 10 years; and NfL, 9 years. Here, NEFL is linked to Alzheimer disease.