PLEC and epidermolysis bullosa simplex: SERPINB4 is a granzyme inhibitor linked with squamous cell carcinomas and chronic liver disease57–59, Plectin mutations are linked with epidermolysis bullosa simplex and may be a susceptibility gene for testicular germ cell tumors60–62, and UQCRQ is a nuclear protein in the mitochondrial respiratory chain complex III essential for brain development63.