APOE and Alzheimer disease: A basic model (BM) was developed, incorporating established risk factors for AD, including age, gender, years of education, and the presence of the APOE ε4 allele; it yielded an AUC of 0.644 (CI 0.540–0.773), with a sensitivity of 31.1%, a specificity of 68.9% (P = 0.012).