- CHAC1 is upregulated in APAP-induced ALI and degrades GSH, contributing to ferroptosis- Salidroside inhibits CHAC1 expression via suppression of the PERK-eIF2α-ATF4 axis, reducing GSH degradation- Salidroside activates the AMPK/SIRT1 pathway, further enhancing its protective effect by inhibiting CHAC1-mediated ferroptosis. The gene discussed is EIF2A; the disease is acute respiratory distress syndrome.