In respiratory diseases, such as bleomycin-induced lung injury and bronchopulmonary dysplasia, CHAC1 contributes to the resolution of inflammation by promoting the apoptosis of immune cells, but its role in oxidative stress also highlights its damaging potential (Figure 8) (Yang M. et al., 2023; Allawzi et al., 2019). This evidence concerns the gene CHAC1 and respiratory system disorder.