However, in conditions like ischemic stroke and spinal cord injury, CHAC1 promotes neuronal damage by inducing ferroptosis through the depletion of GSH, a critical antioxidant, exacerbating oxidative stress and worsening the injury (Mei et al., 2017; Chen M. et al., 2021; Kolnik et al., 2022; Wang et al., 2023; Kang et al., 2022; Li J. et al., 2021) (Figure 6). Here, CHAC1 is linked to ischemic stroke.