AQP4 and Cognitive impairment: There is evidence about the AQP-4 function in cognitive abilities, documented by 1) participation in basic mechanisms affecting cognitive functions such as Long-term potentiation (LTP)and Long-Term Depression (LTD) (Scharfman and Binder, 2013, Szu and Binder, 2016), and inducing specific cognitive impairments in-vivo studies with AQP-4 knockout models (Lu et al., 2008, Skucas et al., 2011), and 2) having a role in neurological disease with cognitive impairments (Hubbard et al., 2018).