NFKB1 and Alzheimer disease: Furthermore, fasudil could ameliorate the cognitive symptoms by reinstating PI3-kinase mediated upregulation of oxidative stress biomarker (eNOS) and control over brain proinflammatory factor regulator (NFκB activity) in a rat model of AD (Kumar and Bansal, 2018) and reducing neuronal apoptosis (Wei et al., 2021).