In summary, resveratrol can reduce arthritis inflammation in GA rats, and its mechanism may involve regulating the biosynthesis of arachidonic acid, phenylalanine, tyrosine, and tryptophan, pantothenic acid, and coenzyme A biosynthesis pathways, TCA cycle, and other metabolic pathways to regulate NF-κB, MAPK, JAK/STAT3 signaling pathways, thereby inhibiting acute inflammatory responses during GA attacks. Here, NFKB1 is linked to arthritic joint disease.