Daratumumab has also been shown to be useful in refractory autoimmune diseases, systemic lupus, autoimmune cytopenia, MDA5-positive dermatomyositis, ANCA-associated vasculitis, Sjögren's syndrome, uncontrolled steroid-dependent nephrotic syndrome, and refractory posttransplant nephrotic syndrome associated with autoantibody decrease.11 The gene discussed is IFIH1; the disease is Sjogren syndrome.