However, the Indian C3G family with an FHR1::FHR5 hybrid protein, the high frequency of FHR1–FHR3 deletions in the Indian population, and the high prevalence of autoimmune DEAP-HUS in India suggest a higher frequency of FHR gene cluster variations that may cause C3G. Here, CFHR1 is linked to complement 3 glomerulopathy.