The genetic causes of C3G include mutations in the genes encoding the complement proteins Factor H and C3; the five FHR proteins FHR1, FHR2, FHR3, FHR4, and FHR5; C5; Factor B; Factor I; MCP/CD46; clusterin; properdin; and plasminogen (28–30). The gene discussed is CFHR5; the disease is complement 3 glomerulopathy.