Additionally, PDGFRs (α and β) play a key role in activating the PI3K/Akt/mTOR (phosphatidylinositol 3-phosphate kinase/protein kinase B (PKB)/mammalian Target of Rapamycin) pathway in sarcomas which in turn, initiates a cascade of downstream signaling that promotes cell proliferation and survival, making this pathway a critical target for therapeutic development in sarcomas like mTOR inhibitors (12). This evidence concerns the gene AKT1 and sarcoma.