Furthermore, significant remodeling of the extracellular matrix, evidenced by increased deposition of fibrillary proteins (collagen, laminin, fibronectin) and upregulation of specific glycoproteins (tenascins), proteoglycans (chondroitin sulfates, versican, syndecan), focal adhesion proteins (FAK, vinculin), and degradative enzymes (MMPs) facilitate glioma cell migration and invasion (55). This evidence concerns the gene VCAN and glioma.