Furthermore, significant remodeling of the extracellular matrix, evidenced by increased deposition of fibrillary proteins (collagen, laminin, fibronectin) and upregulation of specific glycoproteins (tenascins), proteoglycans (chondroitin sulfates, versican, syndecan), focal adhesion proteins (FAK, vinculin), and degradative enzymes (MMPs) facilitate glioma cell migration and invasion (55). The gene discussed is PROS1; the disease is central nervous system cancer.