Interestingly, investigations into the genetic variance risk related to intrinsic inhibition of TNFα or TNFR1-TNFα have found no correlation between the age of onset of PD and inhibition of this pathway, indicating that further research is needed to understand the role of necrosis in disease development (Kang et al., 2021). The gene discussed is TNFRSF1A; the disease is Parkinson disease.