In this study we have addressed these important gaps in our knowledge by combining molecular, cell physiological, neuronal network and whole animal studies of a missense variant, c.1838C>T (T613M), the most common ATP1A3 mutation found in patients with RDP.22,23 We provide insights into the contribution of α3-containing Na+/K+-ATPases to the mechanisms controlling ionic homeostasis, neuronal excitability, locomotor network output and motor behaviour. Here, ATP1A3 is linked to dystonia 12.