AGR2 staining was only rarely seen in adrenocortical tumors (4.3%–9.3%) and in renal cell carcinoma (7.8%–26.5%), and mainly absent in melanoma, seminoma, embryonal carcinoma, adrenocortical neoplasms, tumors of the hematopoietic and lymphoid tissues, as well as mesenchymal tumors. This evidence concerns the gene AGR2 and adrenal cortex neoplasm.