BBC3 and neoplasm: A decisive tumor‐suppressive role of FoxOs is present upon cellular damage, which results in FoxO‐mediated induction of pro‐apoptotic genes such as TNFSF10 (TRAIL), FASLG (FasL), BCL2L11 (BIM), or BBC3 (PUMA) [29, 45, 46, 47].