The CCN3/NOV protein binds to multiple cell surface receptors,[38] and is detected in the circulating blood of normal subjects at a concentration of 350 to 400 ng/ml.[39] CCN3/NOV expression was upregulated by inhibiting Notch signaling in mouse colonic epithelial cells.[40] Taken together, these findings suggest the possibility that the CCN3/NOV protein may be a therapeutic target for multiple disorders including DD. Here, CCN3 is linked to dentin dysplasia.