CCN3 and dentin dysplasia: The primary proteome-wide MR analyses using the UKBB and FinnGen GWAS summary statistics commonly prioritized 4 plasma protein levels that were significantly associated with DD risk (Fig. 2), including CCN3/NOV (OR, 0.98; 95% confidence interval [CI], 0.97 to 0.99; P = 1.2 × 10−11 for UKBB.