Myofibroblasts synthesize large amounts of COL1A1, leading to excessive accumulation of extracellular matrix[25] and ultimately to liver fibrosis.[26] LncRNA XIST is an approximately 17,000 base pair long LncRNA that is predominantly encoded on the X chromosome[27] and is an important regulator of X chromosome inactivation, in addition to playing a key role in a variety of physiological and pathological processes. The gene discussed is COL1A1; the disease is Hepatic fibrosis.