In alcohol-treated mouse hepatocytes, inhibition of NEAT1 expression by specific siRNA improved liver function, reduced lipid levels, effectively suppressed inflammatory responses, prevented the occurrence of hepatocyte apoptosis and inhibited the progression of liver fibrosis.[30] In addition, Akhade VS et al[9] found that silencing 1700020I14Rik by shRNA could significantly reduce the expression of 1700020I14Rik in mouse liver tissue, which was accompanied by a significant decrease in serum ALT, AST, TNF-α and IL-6 levels. The gene discussed is NEAT1; the disease is Hepatic fibrosis.