The small molecule antioxidant N-acetylcysteine attenuates alcohol-induced liver injury by scavenging ROS and improving antioxidant capacity.[49] The NOX1/4 inhibitor GKT137831 acts as a dual inhibitor of NOX1 and NOX4, which protects hepatocytes from injury, reduces serum aminotransferase levels and improves hepatic steatosis by reducing ROS and inflammatory mediators.[50] However, the diversity and complexity of LncRNA structures make the design and screening of small molecule drugs challenging. This evidence concerns the gene NOX1 and fatty liver disease.