POMC and congenital adrenal hyperplasia: Elevated 17-hydroxyprogesterone levels, usually >5000 ng/dL in afflicted neonates, corroborate the diagnosis of 21-hydroxylase insufficiency.[28] For virilized females, chromosome tests and pelvic ultrasounds are advised to confirm a XX karyotype and uterus presence.[29] An ACTH stimulation test may be necessary for definitive CAH evaluation in any age group.