Currently, nonalcoholic fatty liver disease is the leading cause of liver cancer in Western countries due to the increased prevalence rate of metabolic syndrome.[5] Notably, multiple observational studies have shown that hyperuricemia or gout is associated with higher cancer incidence as well as mortality.[6–10] In hepatocellular carcinoma, Guo et al[11] found that hyperuricemia may affect the expression of PDZK1. The gene discussed is PDZK1; the disease is hyperuricemia.