Recent studies show a connection between F nucleatum and OC with high Gal-GalNAc levels indicating a preference for these tumors.[30,34] Microorganisms produce toxins and metabolites in the host’s circulatory system that can affect cancer progression, such as the CagA protein from H pylori, which is associated with tumor development.[35] A healthy estrogen-gut axis is crucial for estrogen metabolism and utilization, while dysbiosis of the estrobolome is indirectly linked to ovarian carcinoma.[36] These findings underscore the significance of GM and metabolites in cancer. This evidence concerns the gene S100A8 and cancer.