The excess load of iron in the liver can cause insulin resistance due to metabolic dysfunction, which can modify the release of adiponectin.[28,63] It is also responsible for the development of other metabolic diseases, such as type 1 and T2DM and obesity.[63] The onset of NAFLD in patients is characterized by insulin resistance, oxidative stress, hyperferritinemia, metabolic disorders and T2DM.[22,61]. The gene discussed is ADIPOQ; the disease is obesity due to melanocortin 4 receptor deficiency.