For example, Pan et al found in a mouse model of periodontitis that excessive loading forces led to increased local expression of YAP, JNK/AP1, tumor necrosis factor α, and interleukin 6, ultimately resulting in increased bone resorption.[30] On the contrary, under intermittent compressive force, the expression of YAP in PDLCs increased, promoting osteogenic differentiation and inhibiting adipogenic differentiation. Here, YAP1 is linked to periodontitis.