Although pathogenicity analysis was performed according to the guidelines for variant interpretation issued by the American Society of Medical Genetics and Genomics (ACMG): c.A4484T, c.A4510G were suspected benign variants using evidence of BP4-Moderate.We still believe that the c.A4484T/c.A4510G mutation in the TRIOBP gene may be a pathogenic variant of hearing loss in the proband. The gene discussed is TRIOBP; the disease is hearing loss disorder.