Proinflammatory cytokines such as IL-1, TNFα, and IL-6 are generated more when inflammation occurs, along with fibrinogen, another acute-phase reactant.[50] According to the study, there is a strong correlation between acute postoperative discomfort and delirium since it stimulates pro-inflammatory mediators to be released more quickly, which in turn accelerates the development of delirium. This evidence concerns the gene TNF and delirium.