ROC curve analyses for NLR, MLR, EOS%, CD4/CD8 and SII to predict DILI occurrence in HBV-TB patients demonstrated an AUC value of 0.671 (95% CI: 0.617–0.724,P < .001) with a positive likelihood ratio of 1.649 for the NLR、AUC value of 0.729 (95% CI: 0.680–0.778,P < .001) with a positive likelihood ratio of 1.868 for MLR、AUC value of 0.744 (95% CI: 0.695–0.793,P < .001)with a positive likelihood ratio of 0.264 for EOS% and AUC value of CD4/CD8 is 0.635 (95% CI: 0.580–0.689, P < .001) with a positive likelihood ratio of 1.377 for CD3/CD4. Here, CD4 is linked to tuberculosis.