In contrast to the effects of BAs, antibiotic treatment had no significant effect on the number of goblet cells or the expression of MUC2. However, regarding the intestinal epithelial barrier, contrary to other reports [50, 57], Salmonella infection significantly increased the expression of the tight junction-related genes CLDN1 and JAM2. This might represent a compensatory response to mucus damage in the intestine. The gene discussed is JAM2; the disease is Salmonella Infections.