Knocking down NDUFC1 evidently impeded the proliferation, cell cycle progression, migration and invasion and triggered apoptotic cell death of hepatocellular carcinoma cells [32] Notably, FLT3-ITD+ AML cell lines (MV4-11, MOLM13 and MOLM14) [5] were more suseptible to genetic intereference with subunits of mitochondiral complex I (NDUFA6 and NDUFC1) and mitochondrial complex II (SDHA). The gene discussed is FLT3; the disease is hepatocellular carcinoma.