AKT1 and neoplasm: In agreement, there was no significant difference in proliferation (Supplementary Figure S4) or ERK, AKT and S6 activation (Fig. 4D) between murine tumor cell lines (mTCL) derived from KrasG12C/tp53KO and KrasG12D/tp53KO GEMMs, further implying that the genotype-specific difference in potency and signaling was lost in established tumors.