RIPK1 and myocardial infarction: Our study not only identified circCacna1c as a master regulator of cardiomyocyte necroptosis but also provides a novel mechanism that connects the dysregulated m6A modification of circRNAs (e.g., circCacna1c) and upregulation of necroptosis associated factors (e.g., RIPK1) in MI-injured cardiomyocyte.