Inhibition of CDK12/13 by treatment of ovarian cancer cells and organoids with THZ531 impaired the splicing and expression also of other genes with strong relevance for tumorigenesis, such as the epidermal growth factor receptor (EGFR) and regulatory associated protein of MTOR complex 1 (RPTOR) genes [59]. The gene discussed is CDK12; the disease is ovarian carcinoma.