MAPT and early-onset autosomal dominant Alzheimer disease: Moreover, we examined other lysosomal damaging agents, such as silica crystals associated with silicosis (Hornung et al, 2008; Mossman and Churg, 1998; Wang et al, 2017) and tau aggregates implicated in Alzheimer’s disease (Flavin et al, 2017; Papadopoulos et al, 2017).