Finally, a targeted prognostic analysis of lung cancer patients using the TCGA database (http://kmplot.com/analysis/) identified that XAF1 expression is more strongly associated with overall survival in TRIM28-high compared to TRIM28-low patient groups and that TRIM28 expression is associated with overall survival in XAF1-high patient group, supporting that the XAF1-TRIM28 interplay plays a role in tumor progression process (Fig. 7e, f). Here, TRIM28 is linked to lung cancer.