Intriguingly, despite clear evidence that NLRP3 inflammasome and IL-1β activity drive obesity and MAFLD (Stienstra et al, 2010, 2011; Vandanmagsar et al, 2011; Coll et al, 2022), whether pyroptosis or other modes of programmed cell death, such as apoptosis and necroptosis, facilitate the demise of key cell types in tissues remains ambiguous. The gene discussed is IL1B; the disease is obesity disorder.