Our findings reveal that although RIPK3 loss and myeloid-specific caspase-8 deletion mostly phenocopy the protection from adipose tissue inflammation, metabolic dysfunction, and steatohepatitis observed in NLRP3 inflammasome–deficient mice (Stienstra et al, 2010, 2011; Vandanmagsar et al, 2011), it failed to prevent adiposity and end-stage insulin resistance. Here, RIPK3 is linked to Insulin resistance.