Obesity-induced inflammation is also inextricably linked to the activation and assembly of the NOD-like receptor protein 3 (NLRP3) inflammasome through the sensing of various metabolic DAMPs (e.g., palmitic acid, cholesterol crystals) (Liang et al, 2021). The gene discussed is NLRP3; the disease is obesity due to melanocortin 4 receptor deficiency.