No overall difference in weight gain or organ mass was observed in genetic control mice lacking caspase-8 only in myeloid cells (Casp8LysMcre), compared with Casp8lox/lox control mice (Fig S3H and I) (Kang et al, 2004; Lawlor et al, 2015), highlighting that loss of caspase-8 may not be sufficient to trigger spontaneous RIPK3-mediated necroptotic inflammation in myeloid cells during obesity. Here, CASP8 is linked to obesity due to melanocortin 4 receptor deficiency.