Nevertheless, reports of elevated RIPK1, RIPK3, and MLKL expression in progressive liver injury and severe MALFD/MASH suggest that hepatocytes may overcome this defect in certain contexts (Gautheron et al, 2014; Saeed et al, 2019; Afonso et al, 2021; Miyata et al, 2021; Hoff et al, 2023). The gene discussed is RIPK3; the disease is metabolic dysfunction-associated steatohepatitis.