IL1B and obesity due to melanocortin 4 receptor deficiency: Intriguingly, despite clear evidence that NLRP3 inflammasome and IL-1β activity drive obesity and MAFLD (Stienstra et al, 2010, 2011; Vandanmagsar et al, 2011; Coll et al, 2022), whether pyroptosis or other modes of programmed cell death, such as apoptosis and necroptosis, facilitate the demise of key cell types in tissues remains ambiguous.