To assess the impact of hG1E-GATA1 treatment of DBA patient samples in vivo, CD34+ HSPCs from RPL5 patient BCH-006 were treated with HMD-GFP or hG1E-GATA1, followed by xenotransplantation into NBSGW mice (Fig. 5A). This evidence concerns the gene CD34 and Diamond-Blackfan anemia.