The main signaling pathways in tumors mainly include the JAK-STAT signaling pathway, p53 signaling pathway, canonical Wnt signaling pathway, Ras signaling pathway, BMP signaling pathway, Notch signaling pathway, etc.21, 22, 23 Through a series of studies, it has been found that these signaling pathways play a crucial role in a variety of malignant tumors. Here, TP53 is linked to cancer.