2 Tanaka Tanaka AJ AJ Bai Bai R R Cho Cho MT MT Anyane-Yeboa Anyane-Yeboa K K Ahimaz Ahimaz P P Wilson Wilson AL AL De novo mutations in PURA are associated with hypotonia and developmental delay De novo mutations in PURA are associated with hypotonia and developmental delay Cold Spring Harb Mol Case Stud Cold Spring Harb Mol Case Stud 2015 2015 1 1 a000356 a000356 a000356 a000356 10.1101/mcs.a000356 10.1101/mcs.a000356 27148565 27148565. This evidence concerns the gene PURA and Global developmental delay.