MAP3K1 and neoplasm: Moreover, we confirmed that silencing Ddx17 could increase surface MHC-I and OVA antigen expression of Map3k1-mut tumor cells, as measured by both immunofluorescence (Supplemental Figure 8C) and flow cytometry (Supplemental Figure 8, D and E, and Supplemental Figure 9, A–D), and thus enhanced the activation of CD8+ T cells in the coculture system.