PCYT2 and colorectal carcinoma: In concert with the finding of PCYT2-mediated YAP1 relocation, overexpression of PEBP1 in CRC cells led to a significant increase in p-YAP1 accumulation in the cytoplasm and a decrease in YAP1 accumulation in the nucleus (Figure 5A), suggesting that YAP1 may undergo ubiquitination and protein degradation.