C5AR1 and Stroke: Moreover, inhibition of the C5a-C5aR axis by using the C5 antibody diminished cerebral lesion and improved motor functions in a rat model of stroke [55], and treatment with C5a receptor antagonist—PMX53 significantly decreases ischemia-induced apoptosis of primary mouse cortical neurons subjected to oxygen–glucose deprivation (an in vitro model of hypoxia–ischemia) [56].