The difference in the occurrence of ipsilateral ischemic cerebrovascular events with the variant in asymptomatic ICAS was statistically insignificant (log-rank test, P = 0.19), although the RNF213 variant group exhibited a higher occurrence of ipsilateral ischemic cerebrovascular events than the RNF213 wild-type group (Fig. 2). Here, RNF213 is linked to familial isolated congenital asplenia.