INS and Obesity: In particular, The psPRSs for Obesity were associated with a higher incidence of clinical requirement of insulin treatment (HR 1.06 [95% CI 1.02, 1.10], p=0.0027), albuminuria (HR 1.05 [95% CI 1.02, 1.09], p=0.0041) and CVD (HR 1.08 [95% CI 1.03, 1.13], p=0.0021) while the psPRS for beta cell dysfunction was associated with a lower incidence of heart failure (HR 0.85 [95% CI 0.76, 0.95], p=0.0050).