WT CIC is a transcriptional repressor discovered in Drosophila which is involved in developmental processes (16, 17) and acts as a tumor and metastasis suppressor predominantly through the repression of PEA3 (ETV1, ETV4, and ETV5) family members and negative MAPK pathway (DUSP4/6) regulators (18–21). Here, ETV4 is linked to neoplasm.