PTK2 and central nervous system cancer: The central role of the adhesive machinery in glioma progression was reiterated by mining data from TCGA and the GTEx projects, which showed stage-dependent upregulation of integrins β1 and β3 in the most aggressive glioma subtypes and downregulation in less aggressive forms such as IDH1-mutated gliomas, suggesting that FAK phosphorylation may be upregulated in aggressive and suppressed in less aggressive glioma (34).