PTK2 and central nervous system cancer: To assess the clinical relevance of glioma adhesion to the ECM, we analyzed expression of integrin β1, integrin β3, and FAK in a cohort of patients with glioma using data from TCGA and the GTEx projects (TCGA LGG, WHO grades 2 and 3, n = 523; TCGA GBM, n = 166; GTEx normal brain tissue, n = 1,141) in conjunction with the Xena bioinformatics tool from University of California Santa Cruz (34).