In this study, hallmark‐based pathway enrichment analysis further indicated that 44 regulatory genes between GERD and COVID‐19 were significantly enriched in immune‐activated and inflammation‐related pathways, particularly IL‐6–JAK–STAT3 signaling, inflammatory response, TNFα signaling via NFκB and interferon‐γ response. The gene discussed is TNF; the disease is COVID-19.