AKT1 and cancer: At the same time, AKT helps cancer cells avoid death in the presence of drug-induced apoptosis by inactivating pro-apoptotic factors (67).When EV-carried factors activate the PI3K/AKT/mTOR pathway, drug-resistant cells are less sensitive to apoptosis induced by sorafenib action, and in these drug-resistant cells, phosphorylated AKT, and tumor suppressor phosphatases are down-regulated, leading to drug resistance (68).