For example, the demonstration of a cohort experiment showed that lincRNA00853 in serum-derived EV showed a high degree of specificity in patients with primary hepatocellular carcinoma (HCC), whereas another scientific team observed differential changes in lincRNA by controlling themselves before and after resection of the tumor (46).Thus, there is an opportunity for lincRNA to be used as a diagnostic marker for early HCC, especially in patients with early-stage tumors who have negative AFP test results (46). The gene discussed is AFP; the disease is hepatocellular carcinoma.